Metabolomics reveals metabolic biomarkers of Crohn's disease

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dc.contributor.authorJansson, Janet K.
dc.contributor.authorLucio, Marianna
dc.contributor.authorWilling, Ben
dc.contributor.authorDicksved, Johan
dc.contributor.authorFekete, Ages
dc.contributor.authorTysk, Curt
dc.contributor.authorSchmitt-Kopplin, Philippe
dc.contributor.authorHalfvarson, Jonas
dc.date.accessioned2025-05-01T11:54:12Z
dc.date.available2025-05-01T11:54:12Z
dc.date.issued2009
dc.descriptionThe causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.
dc.identifier.doihttps://doi.org/10.7939/R3TT4G66G
dc.language.isoen
dc.relationhttp://dx.doi.org/10.1371/journal.pone.0006386
dc.relation.isversionofJansson, J. K., Willing, B., Lucio, M., Fekete, A., Dicksved, J., Halfvarson, J., Tysk, C., & Schmitt-Kopplin, P. (2009). Metabolomics reveals metabolic biomarkers of Crohn's disease. PLoS ONE, 4(7), e6386 [10 pages]. http://dx.doi.org/10.1371/journal.pone.0006386
dc.rightsAttribution 4.0 International
dc.subjectMicrobial Metabolism
dc.subjectBile
dc.subjectMetabolites
dc.subjectAmino Acid Metabolism
dc.subjectMetabolic Pathways
dc.subjectFatty Acids
dc.subjectDrug Metabolism
dc.subjectTwins
dc.titleMetabolomics reveals metabolic biomarkers of Crohn's disease
dc.typehttp://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85
ual.jupiterAccesshttp://terms.library.ualberta.ca/public

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