Fibre-Type Specific Nuclear Localisation Patterns of NFAT-isoforms in CLFS Induced Skeletal Muscle Adaptations
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Abstract
The purpose of this investigation was to characterize the nuclear localisation patterns of NFAT-c1, -c2, -c3, and -c4 in relation to chronic low-frequency stimulation induced fibre type transitions. A model has been suggested to describe the roles of all 4 NFAT isoforms in activity-dependent skeletal muscle fibre transformation. The findings of the present study are consistent with different yet related roles for the NFAT isoforms in fast-to-slow fibre type transformation. NFAT-c1 nuclear expression was associated with transition toward slower fibre types (type-I, type-IIA, type-IID(X)), whereas NFAT-c3 nuclear expression was associated with transformations surrounding the type-IIA fibres. The nuclear expression patterns of NFAT-c2 and NFAT-c4 are consistent with their involvement in fibre maintenance and cell survival.