Synthesis of models of the BC ring systems of MPC1001 and MPC1001F
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Dong, S. ( 1,2 ), Gao, J.-M. ( 1 ), Indukuri, K. ( 2 ), & Clive, D. L. J. ( 2 ). (2016). Synthesis of models of the BC ring systems of MPC1001 and MPC1001F. Chemical Communications, 52(53), 8271–8274. https://doi-org.login.ezproxy.library.ualberta.ca/10.1039/c6cc04169h
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Abstract
Description
Piperazinedione 13, representing the BC ring system of the anti-prostate cancer
fungal metabolite MPC1001 was prepared by a route in which a sulfur-stabilized carbanion
derived from 22 cyclizes onto the terminal ester of the chain attached to N1. Another model, 14,
was synthesized by cyclization of an -ketoamide nitrogen onto an ester; 14 represents the BC
rings of MPC1001F.
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http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_b1a7d7d4d402bcce http://purl.org/coar/version/c_71e4c1898caa6e32
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Models of the BC ring systems of MPC1001 and MPC1001F†
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en