Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core/Shell Nanofibers

Abstract

A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly (methyl methacrylate)(PMMA)-Nylon6 core/shell nanofibers and the release characteristics and antibacterial activity of the system were investigated. It was revealed that the system is capable of releasing the drug with a sustained manner through a three stages release in which the release in stage I followed the non-Fickian diffusion; however, Fickian diffusion was proven to be the release mechanism of stages II and III. The diffusion coefficient calculations indicated a significant decrease in the coefficient from stage II to stage III which is believed to be the consequent of fibers crystallization as a result of the long-term incubation in an aqueous solution. Finally, the antibacterial activity of the system was verified by means of optical density (OD) measurements against gram positive L.innocua.