The na+/H+ exchanger in metastasis
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Amith, Schammim Ray, & Fliegel, Larry. (2016). The na+/H+ exchanger in metastasis. Aging-Us, 8(7), 1291-1291. https://doi.org/10.18632/aging.101002
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https://doi.org/10.18632/aging.101002
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Introduction: Triple-negative breast cancer, in which cells lack the expression of estrogen, progesterone, and human epidermal growth factor 2 receptors, is a clinical subtype of breast cancer commonly associated with poor prognosis. It tends to be aggressively metastatic with a high recurrence rate and little response to standard chemotherapy [1]. Mounting evidence suggests that one triggering event in oncogenic transformation is an imbalance in acid-base homeostasis, with an increase in intracellular pH and acidification of the extracellular tumor microenvironment [2].
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http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85
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en