Profiles of Systemic Inflammatory Response Indicated by C-reactive protein in Children Undergoing Ventricular Assist Device Support and Heart Transplantation
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Abstract
C-reactive protein (CRP) is a biomarker of systemic inflammatory response (SIR) which is associated with the extent and activity of disease. The profiles of SIR and the changes of CRP remain unknown in children undergoing ventricular assist device (VAD) support and heart transplantation (HTx). We examined the perioperative measurements of CRP and the clinical implications in children undergoing VAD support and HTx. Preoperative CRP levels were elevated in both groups due to the mechanical circulatory support prior to surgery. VAD implantation was associated with a prolonged SIR, which may also influenced by an insufficient hemodynamics. The SIR was more pronounced in children receiving bi-ventricular than left-ventricular support. HTx induced an intensified SIR, which may be associated with longer cardiopulmonary bypass duration and insufficient hemodynamics. CRP did not predict the length of stay in the intensive care unit or hospital or death in children undergoing VAD support and HTx.