Black History Month is here! Discover ERA research focused on Black experiences in Canada and worldwide. Use our general search below to get started!

Primary structure of a novel gonadotropin-releasing hormone (GnRH) in the brain of a teleost, Pejerrey

Simple item page
dc.contributor.authorSomoza, G.M.
dc.contributor.authorRivier, J.E.
dc.contributor.authorFischer, W.H.
dc.contributor.authorPark, M.K.
dc.contributor.authorChang, J.P.
dc.contributor.authorCraig, A.G.
dc.contributor.authorMontaner, A.D.
dc.contributor.authorSherwood, N.M.
dc.date.accessioned2025-05-01T12:00:22Z
dc.date.available2025-05-01T12:00:22Z
dc.date.issued2001
dc.descriptionThe neuropeptide GnRH is the major regulator of reproduction in vertebrates acting as a first signal from the hypothalamus to pituitary gonadotropes. Three GnRH molecular variants were detected in the brain of a fish, pejerrey (Odontesthes bonariensis), using chromatographic and immunological methods. The present study shows that one form is identical to chicken GnRH-II (sequence analysis and mass spectrometry) and the second one is immunologically and chromatographically similar to salmon GnRH. The third form was proven to be a novel form of GnRH by isolating the peptide from the brain and determining its primary structure by chemical sequencing and mass spectrometry. The sequence of the novel pejerrey GnRH is pGlu-His- Trp-Ser-Phe-Gly-Leu-Ser-Pro-Gly-NH2, which is different from the known forms of the vertebrate and protochordate GnRH family. The new form of GnRH is biologically active in releasing gonadotropin and GH from pituitary cells in an in vitro assay.
dc.identifier.doihttps://doi.org/10.7939/R31C1TJ1X
dc.language.isoen
dc.relation.isversionofMontaner,A.D., Park, M.K.,Fischer, W.H., Craig A.G., Chang, J.P., Somoza, G.M., Rivier, J.E. and Sherwood, N.M. "Primary structure of a novel gonadotropin-releasing hormone (GnRH) in the brain of a teleost, Pejerrey." Endocrinology 142 (2001): 1453-1460.
dc.rightsCopyright © 2001 by The Endocrine Society
dc.subjectChicken GNRH-II
dc.subjectCarassius-auratus
dc.subject3 forms
dc.subjectLamprey brain
dc.subjectHydrochaeris-Hydrochaeris Mammalia
dc.subjectGrowth-hormone
dc.subjectOdonthesthes bonariensis
dc.subjectPituitary-gland
dc.subjectIn-vitro
dc.subjectMolecular-forms
dc.titlePrimary structure of a novel gonadotropin-releasing hormone (GnRH) in the brain of a teleost, Pejerrey
dc.typehttp://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85
ual.jupiterAccesshttp://terms.library.ualberta.ca/public

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Endocrinology_142_2001_1453.pdf
Size:
330.33 KB
Format:
Adobe Portable Document Format
Download

Collections

Journal Articles (Biological Sciences)