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Design and synthesis of arylthiophene-2-Carbaldehydes via suzuki-miyaura reactions and their biological evaluation

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dc.contributor.authorRiaz, Muhammad
dc.contributor.authorZubair, Muhammad
dc.contributor.authorAli, Shaukat
dc.contributor.authorRasool, Nasir
dc.contributor.authorUllah, Aman
dc.contributor.authorNasim, Faiz-ul-Hassan
dc.contributor.authorRashid, Umer
dc.contributor.authorYaqoob, Asma
dc.date.accessioned2025-05-01T11:54:40Z
dc.date.available2025-05-01T11:54:40Z
dc.date.issued2013
dc.descriptionA series of various novel 4-arylthiophene-2-carbaldehyde compounds were synthesized in moderate to excellent yields via Suzuki-Miyaura cross-coupling with different arylboronic pinacol esters/acids. The synthesized products were screened for their antibacterial, haemolytic, antiurease, and nitric oxide (NO) scavenging capabilities and interestingly, almost all products turned out to have good activities. 3-(5-Formyl-thiophene-3-yl)-5-(trifloromethyl)benzonitrile (2d) revealed excellent antibacterial activity, showing an IC50 value of 29.7 µg/mL against Pseudomonas aeruginosa, compared to the standard drug streptomycin with an IC50 value 35.2 µg/mL and was also found to be the best NO scavenger, with an IC50 value of 45.6 µg/mL. Moreover, 4-(3-chloro-4-fluoro-phenyl)thiophene-2-carbaldehyde (2i) exhibited a superior haemolytic action and an outstanding urease inhibition, showing an IC50 value of 27.1 µg/mL.
dc.identifier.doihttps://doi.org/10.7939/R3NC5SS1R
dc.language.isoen
dc.relationhttp://dx.doi.org/10.3390/molecules181214711
dc.relation.isversionofAli, S., Rasool, N., Ullah, A., Nasim, F., Yaqoob, A., Zubair, M., Rashid, U., & Riaz, M. (2013). Design and synthesis of arylthiophene-2-Carbaldehydes via suzuki-miyaura reactions and their biological evaluation. Molecules, 18(12), 14711-14725. http://dx.doi.org/10.3390/molecules181214711
dc.rightsAttribution 4.0 International
dc.subjectAntibacterial
dc.subjectThiophene
dc.subjectAntioxidants
dc.subjectHeamolytic
dc.subjectPd (0) Catalyzed Suzuki Coupling
dc.subjectActivities
dc.subjectAntiurease
dc.titleDesign and synthesis of arylthiophene-2-Carbaldehydes via suzuki-miyaura reactions and their biological evaluation
dc.typehttp://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85
ual.jupiterAccesshttp://terms.library.ualberta.ca/public

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