Response of Lipid Olefinic Protons to In-Vivo Magnetic Resonance Spectroscopy Sequences at 3 T
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Abstract
Magnetic Resonance Spectroscopy (MRS) measurements of lipid unsaturation are relevant in the study of a number of diseases. The olefinic resonance yields a measure of lipid unsaturation and is often obscured by water signal in-vivo. The objective of this work is to investigate the response of lipid olefinic protons to STEAM, one of two standard in-vivo MRS methods (the other being PRESS). STEAM timing parameters were chosen (mixing time = 20 ms, echo time = 100 ms) to sufficiently resolve the olefinic resonance from that of water in-vivo while ensuring that it did not suffer significant signal losses due to J-coupling. The optimized STEAM sequence was employed to acquire signal from spinal bone marrow of four volunteers, and on average it provided 91% more olefinic signal (by area) compared to the signal acquired with a previously optimized PRESS sequence at 3 T.