Body composition indexes of a load-capacity model: Gender- and BMI-specific reference curves

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dc.contributor.authorBroyles, Stephanie
dc.contributor.authorHeymsfield, Steven B.
dc.contributor.authorPrado, Carla M.
dc.contributor.authorKatzmarzyk, Peter T.
dc.contributor.authorWells, Jonathan C. K.
dc.contributor.authorMire, Emily
dc.contributor.authorSiervo, Mario
dc.date.accessioned2025-05-01T11:54:01Z
dc.date.available2025-05-01T11:54:01Z
dc.date.issued2015
dc.descriptionFat mass (FM) and fat-free mass (FFM) are frequently measured to define body composition phenotypes. The load–capacity model integrates the effects of both FM and FFM to improve disease-risk prediction. We aimed to derive age-, gender- and BMI-specific reference curves of load–capacity model indices in an adult population (≥18 years). Cross-sectional study. Dual-energy X-ray absorptiometry was used to measure FM, FFM, appendicular skeletal muscle mass (ASM) and truncal fat mass (TrFM). Two metabolic load–capacity indices were calculated: ratio of FM (kg) to FFM (kg) and ratio of TrFM (kg) to ASM (kg). Age-standardised reference curves, stratified by gender and BMI (<25·0 kg/m2, 25·0–29·9 kg/m2, ≥30·0 kg/m2), were constructed using an LMS approach. Percentiles of the reference curves were 5th, 15th, 25th, 50th, 75th, 85th and 95th. Secondary analysis of data from the 1999–2004 National Health and Nutrition Examination Survey (NHANES). The population included 6580 females and 6656 males. The unweighted proportions of obesity in males and females were 25·5 % and 34·7 %, respectively. The average values of both FM:FFM and TrFM:ASM were greater in female and obese subjects. Gender and BMI influenced the shape of the association of age with FM:FFM and TrFM:ASM, as a curvilinear relationship was observed in female and obese subjects. Menopause appeared to modify the steepness of the reference curves of both indices. This is a novel risk-stratification approach integrating the effects of high adiposity and low muscle mass which may be particularly useful to identify cases of sarcopenic obesity and improve disease-risk prediction.
dc.identifier.doihttps://doi.org/10.7939/R3N873C9P
dc.language.isoen
dc.relationhttp://dx.doi.org/10.1017/S1368980014001918
dc.relation.isversionofSiervo, M., Prado, C. M., Mire, E., Broyles, S., Wells, J. C. K., Heymsfield, S. B., & Katzmarzyk, P. (2015). Body composition indexes of a load-capacity model: Gender- and BMI-specific reference curves. Public Health Nutrition, 18(7), 1245-1254. http://dx.doi.org/10.1017/S1368980014001918
dc.rights© The Authors 2014
dc.subjectAppendicular Skeletal Mass
dc.subjectFat-Free Mass
dc.subjectFat Mass
dc.subjectTruncal Fat Mass
dc.subjectReference Curves
dc.subjectDual-Energy X-Ray Absorptiometry
dc.subjectNHANES
dc.titleBody composition indexes of a load-capacity model: Gender- and BMI-specific reference curves
dc.typehttp://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85
ual.jupiterAccesshttp://terms.library.ualberta.ca/public

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