Fall 2025 theses and dissertations (non-restricted) will be available in ERA on November 17, 2025.

Whole Genome Linkage Disequilibrium Maps in Cattle

Simple item page
dc.contributor.authorSchnabel, R. D.
dc.contributor.authorWang, Z.
dc.contributor.authorMannenl, H.
dc.contributor.authorGill, C. A.
dc.contributor.authorVan Tassell, C. P.
dc.contributor.authorGao, C.
dc.contributor.authorAerts, J.
dc.contributor.authorWilliams, J. L.
dc.contributor.authorNeto, E. D.
dc.contributor.authorMoore, S. S.
dc.contributor.authorMatukumalli, L. K.
dc.contributor.authorCoppieters, W.
dc.contributor.authorMcKay, S. D.
dc.contributor.authorTaylor, J. F.
dc.contributor.authorCrews, D.
dc.contributor.authorMurdoch, B. M.
dc.date.accessioned2025-05-01T12:20:01Z
dc.date.available2025-05-01T12:20:01Z
dc.date.issued2007
dc.descriptionBackground Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine genome organization which will allow the design of studies to associate genetic variation with economically important traits and also provides background information concerning the extent of long range linkage disequilibrium in cattle. Results Linkage disequilibrium was assessed using r2 among all pairs of syntenic markers within eight breeds of cattle from the Bos taurus and Bos indicus subspecies. Bos taurus breeds included Angus, Charolais, Dutch Black and White Dairy, Holstein, Japanese Black and Limousin while Bos indicus breeds included Brahman and Nelore. Approximately 2670 markers spanning the entire bovine autosomal genome were used to estimate pairwise r2 values. We found that the extent of linkage disequilibrium is no more than 0.5 Mb in these eight breeds of cattle. Conclusion Linkage disequilibrium in cattle has previously been reported to extend several tens of centimorgans. Our results, based on a much larger sample of marker loci and across eight breeds of cattle indicate that in cattle linkage disequilibrium persists over much more limited distances. Our findings suggest that 30,000–50,000 loci will be needed to conduct whole genome association studies in cattle.
dc.identifier.doihttps://doi.org/10.7939/R3HZ39
dc.language.isoen
dc.relationhttp://dx.doi.org/10.1186/1471-2156-8-74
dc.relation.isversionofMcKay, S. D., Schnabel, R.D., Murdoch, B.M., Matukumalli, L. K., Aerts, J., W. Coppieters, D. Crews, E. D. Neto, C.A. Gill, C. Gao, H. Mannenl, Wang, Z., C. P. Van Tassell, J. L. Williams, J.F. Taylor, and Moore, S.S. (2007). Whole Genome Linkage Disequilibrium Maps in Cattle. BMC Genetics, 8(74) 12 pg. http://dx.doi.org/10.1186/1471-2156-8-74
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCattle/genetics
dc.subjectGenome
dc.subjectLinkage disequilibrium
dc.subjectMapping/methods
dc.titleWhole Genome Linkage Disequilibrium Maps in Cattle
dc.typehttp://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85
ual.jupiterAccesshttp://terms.library.ualberta.ca/public

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
bmc_genetics_8(74)
Size:
1.02 MB
Format:
Unknown data format
Download

Collections

Journal Articles (Kinsella Ranch)