Chiral Analysis Using Molecular Rotational Resonance Spectroscopy

Abstract

The chirality controlledstructural panoramas of several prototypic chiral molecular systems were studied in a conformational specific manner using molecular rotational resonance spectroscopy. Comprehensive conformational ensemble spaces were explored theoretically to aid the interpretation of rotational spectra observed experimentally. The binding topologies of these chiral aggregates, including binary and ternary complexes were determined, revealing interesting chirality controlled structural preferences. Comprehensive conformational abundance analyses of the chiral molecular systems were carried out. The experimental conformational abundances showed a complex competition between thermodynamically and kinetically controlled formation processes of chiral molecular aggregates under supersonic jet expansion conditions. Furthermore, analytically oriented experiments, including impurity identification and enantiomeric excess measurements were performed using a chirped pulse Fourier transform microwave spectrometer.